Fig. 4

Summary of the potential pathways and mechanisms of genes associated with skin cancer-related phenotypes. (i) BNC2 induces G0/G1 phase arrest, preventing uncontrolled cell division and thereby reducing skin cancer risk; (ii) CLPTM1L is in high linkage disequilibrium with TERT, a gene essential for telomere synthesis and linked to increased skin cancer susceptibility; (iii) LPP promotes angiogenesis and tumourigenesis through activation of the Ras signalling pathway