Fig. 4

Results of the association study between BAT activity and rs1022981 (A) and rs12405556 (B) genotypes. The box plot shows the distribution of the ΔTemp (BAT temperature) values in the genotype groups at the end of the experiment. Age, sex (0 = female, 1 = male), season (summer = 0, winter = 1), ethnicity (Japanese = 0, other = 1), and genotype were included as independent variables. In each box plot, genotypes are shown in the following order: homozygotes of the putatively selected allele (right), heterozygotes (middle), and homozygotes of the counter allele (left). The box plot shows the median values (central line), mean values (cross marks), and 75th and 25th percentiles (upper and lower boundaries, respectively). The largest and smallest values are represented as whiskers drawn from the box ends. Outliers are indicated by dots. ΔTemp was calculated by subtracting the skin surface temperature in the control chest region from that of the supraclavicular fossa region. P-values of genotypes in multiple linear regression models are shown