Fig. 3

Results of the association study between genotypes and CIT and FO. The box plots show the distribution of values for capacity for CIT (kcal/day/kg) (A, B) and ∆Fat oxidation (mg/min) (C, D) in the genotype groups. Associations are shown for rs1022981 (LEPR) (A, C) and rs12405556 (LEPR) (B, D). In each box plot, genotypes are shown in the following order: homozygotes of the putatively selected alleles (right), heterozygotes (middle), and homozygotes of the counter allele (left). The box plot shows the median values (central line), mean values (cross marks), and 75th and 25th percentiles (upper and lower boundaries, respectively). The largest and smallest values are represented as whiskers drawn from the box ends. Outliers are indicated by dots. CIT, cold-induced thermogenesis; FO, fat oxidation. ΔFat oxidation was calculated by subtracting the fat oxidation value of pre-cold exposure from that of post-cold exposure. P-values of genotypes in multiple linear regression models are shown. N.S., not significant